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	<div id="articleTitle"><h3>Actividad antiamiloidogénica in vitro de 3-aminocumarina y 7,8-dihidroxi-6-metoxicumarina</h3></div>
	<div id="authorString"><em>Raquel Asperilla Martín, Amaia Fernández Uriarte</em></div>
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			<div id="articleAbstract">
		<h4>Resumen</h4>
		<br />
		<div>El desarrollo de fármacos con potencial terapéutico en la enfermedad de Alzheimer es uno de los objetivos principales en terapéutica, ya que la enfermedad constituye un grave problema sociosanitario a nivel mundial. Parece ser que una parte importante de la patogenia de la enfermedad está relacionada con el estrés oxidativo, frente al cual estudios anteriores revelan que las cumarinas, compuestos ampliamente distribuidos en la naturaleza, son activas por su capacidad neuroprotectora. Por este motivo, en el presente estudio probamos la eficacia de dos cumarinas (3-aminocumarina y fraxetol) en diferentes dianas del proceso amiloidogénico. Nuestros estudios ponen de manifiesto que 3-aminocumarina y 7,8-dihidroxi-6-metoxicumarina poseen propiedades antiamiloidogénicas, ya que son activos como inhibidores de β-secretasa, moduladoras de g-secretasa, inhibidores de la agregación y desagregantes del péptido β-amiloide 25-35.</div>
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		<h4>Palabras clave</h4>
		<br />
		<div>Enfermedad de Alzheimer; Cumarinas;</div>
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