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	<meta name="DC.Description" xml:lang="es" content=" En la actualidad se estima que aproximadamente 35 millones de personas   en el mundo están infectadas por el virus causante del SIDA; del mismo modo, diversos estudios indican que, de la población total de gatos domésticos (unos 230 millones), aproximadamente el 11% convive con su propia versión de la enfermedad. A través de una revisión bibliográfica se ponen de manifiesto algunas de las similitudes y diferencias más importantes entre los agentes causantes (VIH y VIF). Se recuerda el proceso de infección de estos virus y se ahonda en los mecanismos de resistencia específica a dicha infección, la llamada  inmunidad intrínseca  en las células hospedadoras, en la que se han descrito dos clases de proteínas celulares que interfieren específicamente con infecciones retrovirales a nivel celular: los factores de restricción (APOBEC3,TRIMCyp). Las similitudes entre ambos retrovirus permiten el desarrollo de innovadoras estrategias para combatir el virus que afecta al ser humano, siendo éste el causante del fallecimiento de unos 36 millones de personas desde el comienzo de la pandemia. "/>
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	<div id="articleTitle"><h3>Gatos transgénicos en la lucha contra el sida</h3></div>
	<div id="authorString"><em>Juliana Rodríguez García, Natalia López Gómez</em></div>
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		<h4>Resumen</h4>
		<br />
		<div>En la actualidad se estima que aproximadamente 35 millones de personas<strong> </strong>en el mundo están infectadas por el virus causante del SIDA; del mismo modo, diversos estudios indican que, de la población total de gatos domésticos (unos 230 millones), aproximadamente el 11% convive con su propia versión de la enfermedad. A través de una revisión bibliográfica se ponen de manifiesto algunas de las similitudes y diferencias más importantes entre los agentes causantes (VIH y VIF). Se recuerda el proceso de infección de estos virus y se ahonda en los mecanismos de resistencia específica a dicha infección, la llamada <em>inmunidad intrínseca</em> en las células hospedadoras, en la que se han descrito dos clases de proteínas celulares que interfieren específicamente con infecciones retrovirales a nivel celular: los factores de restricción (APOBEC3,TRIMCyp). Las similitudes entre ambos retrovirus permiten el desarrollo de innovadoras estrategias para combatir el virus que afecta al ser humano, siendo éste el causante del fallecimiento de unos 36 millones de personas desde el comienzo de la pandemia.</div>
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		<h4>Palabras clave</h4>
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		<div>Gatos transgénicos; VIF; VIH; APOBEC3; TRIMCyp;</div>
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