array (
  'accessLogFileParseRegex' => '/^(?P<ip>\\S+) \\S+ \\S+ \\[(?P<date>.*?)\\] "\\S+ (?P<url>\\S+).*?" (?P<returnCode>\\S+) \\S+ ".*?" "(?P<userAgent>.*?)"/',
  'createLogFiles' => true,
  'enabled' => true,
  'optionalColumns' => 
  array (
    0 => 'city',
    1 => 'region',
  ),
); ?>array (
  'enabled' => true,
); ?>array (
  'crontab' => 
  array (
    0 => 
    array (
      'className' => 'plugins.generic.usageStats.UsageStatsLoader',
      'frequency' => 
      array (
        'hour' => 24,
      ),
      'args' => 
      array (
        0 => 'autoStage',
      ),
    ),
    1 => 
    array (
      'className' => 'plugins.generic.pln.classes.tasks.Depositor',
      'frequency' => 
      array (
        'hour' => '25',
      ),
      'args' => 
      array (
        0 => 'autoStage',
      ),
    ),
    2 => 
    array (
      'className' => 'plugins.importexport.crossref.CrossrefInfoSender',
      'frequency' => 
      array (
        'hour' => 24,
      ),
      'args' => 
      array (
      ),
    ),
    3 => 
    array (
      'className' => 'plugins.importexport.crossref.CrossrefInfoSender',
      'frequency' => 
      array (
        'hour' => 24,
      ),
      'args' => 
      array (
      ),
    ),
    4 => 
    array (
      'className' => 'plugins.importexport.medra.MedraInfoSender',
      'frequency' => 
      array (
        'hour' => 24,
      ),
      'args' => 
      array (
      ),
    ),
    5 => 
    array (
      'className' => 'plugins.importexport.datacite.DataciteInfoSender',
      'frequency' => 
      array (
        'hour' => 24,
      ),
      'args' => 
      array (
      ),
    ),
    6 => 
    array (
      'className' => 'classes.tasks.ReviewReminder',
      'frequency' => 
      array (
        'hour' => 24,
      ),
      'args' => 
      array (
      ),
    ),
    7 => 
    array (
      'className' => 'classes.tasks.SubscriptionExpiryReminder',
      'frequency' => 
      array (
        'hour' => 24,
      ),
      'args' => 
      array (
      ),
    ),
    8 => 
    array (
      'className' => 'classes.tasks.OpenAccessNotification',
      'frequency' => 
      array (
        'hour' => 24,
      ),
      'args' => 
      array (
      ),
    ),
  ),
  'enabled' => true,
); ?>array (
  'ca_ES' => 
  array (
    'key' => 'ca_ES',
    'complete' => 'false',
    'name' => 'Català',
    'iso639-2b' => 'cat',
    'iso639-3' => 'cat',
  ),
  'cs_CZ' => 
  array (
    'key' => 'cs_CZ',
    'complete' => 'true',
    'name' => 'Čeština',
    'iso639-2b' => 'cze',
    'iso639-3' => 'ces',
  ),
  'da_DK' => 
  array (
    'key' => 'da_DK',
    'complete' => 'false',
    'name' => 'Dansk',
    'iso639-2b' => 'dan',
    'iso639-3' => 'dan',
  ),
  'de_DE' => 
  array (
    'key' => 'de_DE',
    'complete' => 'true',
    'name' => 'Deutsch',
    'iso639-2b' => 'ger',
    'iso639-3' => 'deu',
  ),
  'el_GR' => 
  array (
    'key' => 'el_GR',
    'complete' => 'false',
    'name' => 'ελληνικά',
    'iso639-2b' => 'gre',
    'iso639-3' => 'ell',
  ),
  'en_US' => 
  array (
    'key' => 'en_US',
    'complete' => 'true',
    'name' => 'English',
    'iso639-2b' => 'eng',
    'iso639-3' => 'eng',
  ),
  'es_AR' => 
  array (
    'key' => 'es_AR',
    'complete' => 'false',
    'name' => 'Español (Argentina)',
    'iso639-2b' => 'spa',
    'iso639-3' => 'spa',
  ),
  'es_ES' => 
  array (
    'key' => 'es_ES',
    'complete' => 'true',
    'name' => 'Español (España)',
    'iso639-2b' => 'spa',
    'iso639-3' => 'spa',
  ),
  'eu_ES' => 
  array (
    'key' => 'eu_ES',
    'complete' => 'false',
    'name' => 'Euskara',
    'iso639-2b' => 'eus',
    'iso639-3' => 'eus',
  ),
  'fa_IR' => 
  array (
    'key' => 'fa_IR',
    'complete' => 'false',
    'name' => 'فارسی',
    'iso639-2b' => 'per',
    'iso639-3' => 'fas',
  ),
  'fr_CA' => 
  array (
    'key' => 'fr_CA',
    'complete' => 'true',
    'name' => 'Français (Canada)',
    'iso639-2b' => 'fre',
    'iso639-3' => 'fra',
  ),
  'fr_FR' => 
  array (
    'key' => 'fr_FR',
    'complete' => 'true',
    'name' => 'Français (France)',
    'iso639-2b' => 'fre',
    'iso639-3' => 'fra',
  ),
  'gl_ES' => 
  array (
    'key' => 'gl_ES',
    'complete' => 'false',
    'name' => 'Galego',
    'iso639-2b' => 'glg',
    'iso639-3' => 'glg',
  ),
  'hr_HR' => 
  array (
    'key' => 'hr_HR',
    'complete' => 'false',
    'name' => 'Hrvatski',
    'iso639-2b' => 'hrv',
    'iso639-3' => 'hrv',
  ),
  'id_ID' => 
  array (
    'key' => 'id_ID',
    'complete' => 'false',
    'name' => 'Bahasa Indonesia',
    'iso639-2b' => 'ind',
    'iso639-3' => 'ind',
  ),
  'it_IT' => 
  array (
    'key' => 'it_IT',
    'complete' => 'false',
    'name' => 'Italiano',
    'iso639-2b' => 'ita',
    'iso639-3' => 'ita',
  ),
  'ja_JP' => 
  array (
    'key' => 'ja_JP',
    'complete' => 'false',
    'name' => '日本語',
    'iso639-2b' => 'jpn',
    'iso639-3' => 'jpn',
  ),
  'mk_MK' => 
  array (
    'key' => 'mk_MK',
    'complete' => 'false',
    'name' => 'Македонски јазик',
    'iso639-2b' => 'mac',
    'iso639-3' => 'mkd',
  ),
  'ml_IN' => 
  array (
    'key' => 'ml_IN',
    'complete' => 'false',
    'name' => 'മലയാളം',
    'iso639-2b' => 'mal',
    'iso639-3' => 'mal',
  ),
  'nl_NL' => 
  array (
    'key' => 'nl_NL',
    'complete' => 'true',
    'name' => 'Nederlands',
    'iso639-2b' => 'dut',
    'iso639-3' => 'nld',
  ),
  'no_NO' => 
  array (
    'key' => 'no_NO',
    'complete' => 'false',
    'name' => 'Norsk',
    'iso639-2b' => 'nor',
    'iso639-3' => 'nor',
  ),
  'pl_PL' => 
  array (
    'key' => 'pl_PL',
    'complete' => 'false',
    'name' => 'Język Polski',
    'iso639-2b' => 'pol',
    'iso639-3' => 'pol',
  ),
  'pt_BR' => 
  array (
    'key' => 'pt_BR',
    'complete' => 'true',
    'name' => 'Português (Brasil)',
    'iso639-2b' => 'por',
    'iso639-3' => 'por',
  ),
  'pt_PT' => 
  array (
    'key' => 'pt_PT',
    'complete' => 'true',
    'name' => 'Português (Portugal)',
    'iso639-2b' => 'por',
    'iso639-3' => 'por',
  ),
  'ro_RO' => 
  array (
    'key' => 'ro_RO',
    'complete' => 'false',
    'name' => 'Limba Română',
    'iso639-2b' => 'rum',
    'iso639-3' => 'ron',
  ),
  'ru_RU' => 
  array (
    'key' => 'ru_RU',
    'complete' => 'false',
    'name' => 'Русский',
    'iso639-2b' => 'rus',
    'iso639-3' => 'rus',
  ),
  'sk_SK' => 
  array (
    'key' => 'sk_SK',
    'complete' => 'false',
    'name' => 'Slovenčina',
    'iso639-2b' => 'slk',
    'iso639-3' => 'slk',
  ),
  'sr_SR' => 
  array (
    'key' => 'sr_SR',
    'complete' => 'false',
    'name' => 'Cрпски',
    'iso639-2b' => 'srp',
    'iso639-3' => 'srp',
  ),
  'sv_SE' => 
  array (
    'key' => 'sv_SE',
    'complete' => 'false',
    'name' => 'Svenska',
    'iso639-2b' => 'swe',
    'iso639-3' => 'swe',
  ),
  'tr_TR' => 
  array (
    'key' => 'tr_TR',
    'complete' => 'true',
    'name' => 'Türkçe',
    'iso639-2b' => 'tur',
    'iso639-3' => 'tur',
  ),
  'uk_UA' => 
  array (
    'key' => 'uk_UA',
    'complete' => 'false',
    'name' => 'Українська',
    'iso639-2b' => 'ukr',
    'iso639-3' => 'ukr',
  ),
  'vi_VN' => 
  array (
    'key' => 'vi_VN',
    'complete' => 'false',
    'name' => 'Tiếng Việt',
    'iso639-2b' => 'vie',
    'iso639-3' => 'vie',
  ),
  'zh_CN' => 
  array (
    'key' => 'zh_CN',
    'complete' => 'true',
    'name' => '简体中文',
    'iso639-2b' => 'chi',
    'iso639-3' => 'zho',
  ),
  'zh_TW' => 
  array (
    'key' => 'zh_TW',
    'complete' => 'false',
    'name' => '繁體中文',
    'iso639-2b' => 'chi',
    'iso639-3' => 'zho',
  ),
  'ar_IQ' => 
  array (
    'key' => 'ar_IQ',
    'complete' => 'true',
    'name' => 'العربية',
    'iso639-2b' => 'ara',
    'iso639-3' => 'ara',
    'stylesheet' => 'lib/pkp/styles/rtl-arabic.css',
  ),
); ?>array (
  'enabled' => true,
  'seq' => 7,
  'context' => 2,
); ?>array (
  'enabled' => true,
  'seq' => 1,
  'context' => 2,
); ?>array (
  'context' => 2,
  'enabled' => true,
  'seq' => 6,
); ?>array (
  'context' => 2,
  'enabled' => true,
  'seq' => 3,
); ?>array (
  'context' => 2,
  'enabled' => true,
  'seq' => 4,
); ?>array (
  'context' => 2,
  'enabled' => true,
  'seq' => 2,
); ?>array (
  'enabled' => true,
  'seq' => 9,
  'context' => 2,
); ?>array (
  'enabled' => true,
  'seq' => 0,
  'context' => 2,
); ?>array (
  'context' => 2,
  'enabled' => true,
  'seq' => 5,
); ?>array (
  'enabled' => true,
  'seq' => 8,
  'context' => 2,
); ?><?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN"
	"http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html xmlns="http://www.w3.org/1999/xhtml" lang="es-ES" xml:lang="es-ES">
<head>
	<title>Sobrecarga de hierro en la β-talasemia. Una revisión de los antiguos y nuevos quelantes con aplicación clínica | Maldonado Barrueco | REDUCA</title>
	<meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
	<meta name="description" content="Sobrecarga de hierro en la β-talasemia. Una revisión de los antiguos y nuevos quelantes con aplicación clínica" />
			<meta name="keywords" content="β-talasemia; Ferritina; Quelatoterapia; Transfusión; Hemocromatosis;" />
	
	
	<link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" />

	<meta name="DC.Contributor.Sponsor" xml:lang="es" content=""/>
	<meta name="DC.Coverage" xml:lang="es" content=""/>
	<meta name="DC.Coverage.spatial" xml:lang="es" content=""/>
	<meta name="DC.Coverage.temporal" xml:lang="es" content=""/>
	<meta name="DC.Creator.PersonalName" content="Alfredo Maldonado Barrueco"/>
	<meta name="DC.Creator.PersonalName" content="Begoña San Román Salmador"/>
	<meta name="DC.Date.available" scheme="ISO8601" content="2014-02-24"/>
	<meta name="DC.Date.created" scheme="ISO8601" content="2014-02-26"/>
	<meta name="DC.Date.dateSubmitted" scheme="ISO8601" content="2014-02-26"/>
	<meta name="DC.Date.issued" scheme="ISO8601" content="2014-02-24"/>
	<meta name="DC.Date.modified" scheme="ISO8601" content="2014-02-26"/>
	<meta name="DC.Description" xml:lang="es" content=" La talasemia es un trastorno hereditario que afecta a la producción de hemoglobina normal, incluyendo muchas formas diferentes de anemia. La β-talasemia, en la cual nos centraremos, es causada por mutaciones en las cadenas beta de la molécula de hemoglobina. Existe un gen para la cadena beta en cada cromosoma número 11, con un total de dos genes.     La forma en que estos genes están alterados determinará el tipo específico de beta talasemia en una persona: beta talasemia grave ( anemia de Cooley ), beta talasemia intermedia o beta talasemia leve. Así, en este trabajo, haremos una revisión de los tratamientos farmacológicos utilizados en estos pacientes a lo largo de los últimos 8 años centrándonos en una de las principales causas secundarias de su tratamiento: la acumulación de hierro que puede originar hemosiderosis y hemocromatosis en los dos primeros tipos clínicos. "/>
	<meta name="DC.Format" scheme="IMT" content="application/pdf"/>
	<meta name="DC.Identifier" content="1652"/>
	<meta name="DC.Identifier.URI" content="https://revistareduca.es/index.php/reduca/article/view/1652"/>
	<meta name="DC.Language" scheme="ISO639-1" content="es"/>
	<meta name="DC.Rights" content="Copyright (c)  " />
	<meta name="DC.Rights" content=""/>
	<meta name="DC.Source" content="REDUCA"/>
	<meta name="DC.Source.ISSN" content="1989-5003"/>
	<meta name="DC.Source.Issue" content="1"/>	<meta name="DC.Source.URI" content="https://revistareduca.es/index.php/reduca"/>
	<meta name="DC.Source.Volume" content="6"/>						<meta name="DC.Subject" xml:lang="es" content="β-talasemia"/>
								<meta name="DC.Subject" xml:lang="es" content="Ferritina"/>
								<meta name="DC.Subject" xml:lang="es" content="Quelatoterapia"/>
								<meta name="DC.Subject" xml:lang="es" content="Transfusión"/>
								<meta name="DC.Subject" xml:lang="es" content="Hemocromatosis;"/>
				<meta name="DC.Title" content="Sobrecarga de hierro en la β-talasemia. Una revisión de los antiguos y nuevos quelantes con aplicación clínica"/>
		<meta name="DC.Type" content="Text.Serial.Journal"/>
	<meta name="DC.Type.articleType" content="Congresos de alumnos"/>
		<meta name="gs_meta_revision" content="1.1" />
	<meta name="citation_journal_title" content="REDUCA"/>
	<meta name="citation_issn" content="1989-5003"/>
        <meta name="citation_author" content="Alfredo Maldonado Barrueco"/>
        <meta name="citation_author" content="Begoña San Román Salmador"/>
<meta name="citation_title" content="Sobrecarga de hierro en la β-talasemia. Una revisión de los antiguos y nuevos quelantes con aplicación clínica"/>

	<meta name="citation_date" content="2014/02/26"/>

	<meta name="citation_volume" content="6"/>
	<meta name="citation_issue" content="1"/>

	<meta name="citation_abstract_html_url" content="https://revistareduca.es/index.php/reduca/article/view/1652"/>
	<meta name="citation_language" content="es"/>
						<meta name="citation_keywords" xml:lang="es" content="β-talasemia"/>
								<meta name="citation_keywords" xml:lang="es" content="Ferritina"/>
								<meta name="citation_keywords" xml:lang="es" content="Quelatoterapia"/>
								<meta name="citation_keywords" xml:lang="es" content="Transfusión"/>
								<meta name="citation_keywords" xml:lang="es" content="Hemocromatosis;"/>
									<meta name="citation_pdf_url" content="https://revistareduca.es/index.php/reduca/article/download/1652/1673"/>
				

	<link rel="stylesheet" href="https://revistareduca.es/lib/pkp/styles/pkp.css" type="text/css" />
	<link rel="stylesheet" href="https://revistareduca.es/lib/pkp/styles/common.css" type="text/css" />
	<link rel="stylesheet" href="https://revistareduca.es/styles/common.css" type="text/css" />
	<link rel="stylesheet" href="https://revistareduca.es/styles/compiled.css" type="text/css" />
	<link rel="stylesheet" href="https://revistareduca.es/styles/articleView.css" type="text/css" />
	
	
	
				
	
	<!-- Base Jquery -->
	<script type="text/javascript" src="//www.google.com/jsapi"></script>
	<script type="text/javascript">
		// Provide a local fallback if the CDN cannot be reached
		if (typeof google == 'undefined') {
			document.write(unescape("%3Cscript src='https://revistareduca.es/lib/pkp/js/lib/jquery/jquery.min.js' type='text/javascript'%3E%3C/script%3E"));
			document.write(unescape("%3Cscript src='https://revistareduca.es/lib/pkp/js/lib/jquery/plugins/jqueryUi.min.js' type='text/javascript'%3E%3C/script%3E"));
		} else {
			google.load("jquery", "1.4.4");
			google.load("jqueryui", "1.8.6");
		}
	</script>
	
	<!-- Compiled scripts -->
			
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/lib/jquery/plugins/jquery.tag-it.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/lib/jquery/plugins/jquery.cookie.js"></script>

<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/functions/fontController.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/functions/general.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/functions/jqueryValidatorI18n.js"></script>

<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/classes/Helper.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/classes/ObjectProxy.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/classes/Handler.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/classes/linkAction/LinkActionRequest.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/classes/features/Feature.js"></script>

<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/controllers/SiteHandler.js"></script><!-- Included only for namespace definition -->
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/controllers/UrlInDivHandler.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/controllers/AutocompleteHandler.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/controllers/ExtrasOnDemandHandler.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/controllers/form/FormHandler.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/controllers/form/AjaxFormHandler.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/controllers/form/ClientFormHandler.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/controllers/grid/GridHandler.js"></script>
<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/controllers/linkAction/LinkActionHandler.js"></script>

<script type="text/javascript" src="https://revistareduca.es/js/pages/search/SearchFormHandler.js"></script>
<script type="text/javascript" src="https://revistareduca.es/js/statistics/ReportGeneratorFormHandler.js"></script>
<script type="text/javascript" src="https://revistareduca.es/plugins/generic/lucene/js/LuceneAutocompleteHandler.js"></script>

<script type="text/javascript" src="https://revistareduca.es/lib/pkp/js/lib/jquery/plugins/jquery.pkp.js"></script>	
	
	<script type="text/javascript" src="https://revistareduca.es/js/relatedItems.js"></script>
	<script type="text/javascript" src="https://revistareduca.es/js/inlinePdf.js"></script>
	<script type="text/javascript" src="https://revistareduca.es/js/pdfobject.js"></script>

</head>
<body id="pkp-common-openJournalSystems">

<div id="container">

<div id="header">
<div id="headerTitle">
<h1>
	REDUCA
</h1>
</div>
</div>

<div id="body">


<div id="main">

<div id="navbar">
	<ul class="menu">
		<li id="home"><a href="https://revistareduca.es/index.php/reduca/index">Inicio</a></li>
		<li id="about"><a href="https://revistareduca.es/index.php/reduca/about">Acerca de</a></li>

					<li id="login"><a href="https://revistareduca.es/index.php/reduca/login">Iniciar sesión</a></li>
							<li id="register"><a href="https://revistareduca.es/index.php/reduca/user/register">Registrarse</a></li>
												<li id="search"><a href="https://revistareduca.es/index.php/reduca/search">Buscar</a></li>
		
					<li id="current"><a href="https://revistareduca.es/index.php/reduca/issue/current">Actual</a></li>
			<li id="archives"><a href="https://revistareduca.es/index.php/reduca/issue/archive">Archivos</a></li>
		
				

								</ul>
</div>
<div id="breadcrumb">
	<a href="https://revistareduca.es/index.php/reduca/index" target="_parent">Inicio</a> &gt;
	<a href="https://revistareduca.es/index.php/reduca/issue/view/120" target="_parent">Vol. 6, Núm. 1 (2014)</a> &gt;	<a href="https://revistareduca.es/index.php/reduca/article/view/1652/0" class="current" target="_parent">Maldonado Barrueco</a>
</div>

<div id="content">


	<div id="topBar">
					</div>
		
	<div id="articleTitle"><h3>Sobrecarga de hierro en la β-talasemia. Una revisión de los antiguos y nuevos quelantes con aplicación clínica</h3></div>
	<div id="authorString"><em>Alfredo Maldonado Barrueco, Begoña San Román Salmador</em></div>
	<br />
			<div id="articleAbstract">
		<h4>Resumen</h4>
		<br />
		<div>La talasemia es un trastorno hereditario que afecta a la producción de hemoglobina normal, incluyendo muchas formas diferentes de anemia. La β-talasemia, en la cual nos centraremos, es causada por mutaciones en las cadenas beta de la molécula de hemoglobina. Existe un gen para la cadena beta en cada cromosoma número 11, con un total de dos genes. La forma en que estos genes están alterados determinará el tipo específico de beta talasemia en una persona: beta talasemia grave (<em>anemia de Cooley</em>), beta talasemia intermedia o beta talasemia leve. Así, en este trabajo, haremos una revisión de los tratamientos farmacológicos utilizados en estos pacientes a lo largo de los últimos 8 años centrándonos en una de las principales causas secundarias de su tratamiento: la acumulación de hierro que puede originar hemosiderosis y hemocromatosis en los dos primeros tipos clínicos.</div>
		<br />
		</div>
	
			<div id="articleSubject">
		<h4>Palabras clave</h4>
		<br />
		<div>β-talasemia; Ferritina; Quelatoterapia; Transfusión; Hemocromatosis;</div>
		<br />
		</div>
	
				
			<div id="articleFullText">
		<h4>Texto completo:</h4>
									<a href="https://revistareduca.es/index.php/reduca/article/view/1652/1673" class="file" target="_parent">PDF</a>
														</div>
	
	
	



		

</div><!-- content -->
</div><!-- main -->
</div><!-- body -->



</div> <!-- container -->
</body>
</html>