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	<div id="articleTitle"><h3>Explorando los mecanismos de interacción con el ADN en Inhibidores de topoisomerasa I de nueva síntesis</h3></div>
	<div id="authorString"><em>Miguel Largo Almoguera</em></div>
	<br />
			<div id="articleAbstract">
		<h4>Resumen</h4>
		<br />
		<div>Algunos fármacos antitumorales son capaces de inhibir enzimas fundamentales en los procesos de crecimiento y replicación celulares anómalos que presentan las células tumorales.<strong> </strong>En otros casos, el mecanismo de acción pasa por la intercalación de los fármacos en el ADN. Por ello, las técnicas de análisis que puedan evidenciar este mecanismo son cruciales en el proceso de desarrollo de nuevos fármacos. En nuestro trabajo hemos utilizado una de estas técnicas, la viscosimetría, capaz de cuantificar el aumento de la viscosidad cuando la cadena de ADN se alarga tras la intercalación de un fármaco. </div>
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		<h4>Palabras clave</h4>
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		<div>Intercalantes; ADN; Antitumorales; Viscosimetría;</div>
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</div> <!-- container -->
</body>
</html>